We use cookies to offer you a better experience, personalize content, tailor advertising, provide social media features, and better understand the use of our services. Pdf ovarian metastasis was described the first time by friedrich ernst krukenberg in 1896. Abstractkrukenberg tumors accompanied by gestational hypertension are rare and have a poor. Gastric adenocarcinoma, especially at the pylorus, is the most common source. Worldwide, they account for about 1% of all ovarian neoplasms. Krukenberg tumor is a metastatic cancerous development spread from stomach to ovary. Survival benefit of metastasectomy for krukenberg tumors from. A krukenberg tumor is a rare ovarian tumor which has metastasized from a. Clinical characteristics and prognostic analysis of krukenberg tumor. The primary lesion of krukenberg tumor is frequently from stomach but may also be from colon, biliary tract, appendix, breast and gall bladder. A total of 156 consecutive patients diagnosed with kts of the ovary. A krukenberg tumor refers to a subtype of metastatic tumor to the ovary.
This tumor is named after friedrich ernst krukenberg 18711946, who. Krukenberg tumor introduction heterogeneous intratumoral f18 fluorodeoxyglucose fdg uptake is observed in some types of benign and malignant tumors 1, 2, and kidd et al. Get a printable copy pdf file of the complete article 1. H major revealed the true metastatic nature of the tumor. Decades later it was confirmed that krukenberg tumor is in fact a metastasis of signet ring cells typically from gastric adenocarcinoma which is associated with. Is a surgical approach justified in metachronous krukenberg tumor. Here, we report a very rare case of bilateral krukenberg tumors of the ovaries arising from a. Here we report a case of virilization associated with an extensive. Since the time of krukenberg in 1896, all ovarian tumors which enlarge the ovaries uniformly without distortion, which present alterations of fibrous areas with mucinouscell groups, and which propagate along the lymphatics are called krukenberg tumors 6. Krukenburg tumor is a metastatic malignancy of the ovary characterized. This study aims to describe the unusual case of a 36yearold woman that presented to the emergency department ed with back pain and a positive urine pregnancy test.
In this case, the treatment is guided by histopathological findings. A krukenberg tumor is a malignancy in the ovary that metastasizes from a primary site. The preoperative diagnosis of a krukenberg tumor was made based on the clinical suspicions, a physical examination, a pelvic ultrasound, as well as abdominal and pelvic ct scans. The ct showed a complex cystic mass that seens to be related to ovary neoplasms. The stomach is the primary site in the majority 75% of krukenberg tumor cases, followed by carcinomas of the colon, appendix, and breast 14. For language access assistance, contact the ncats public information officer.
Krukenberg tumors definition of krukenberg tumors by. Treatment of patients with krukenberg tumor is controversial. Krukenberg tumor definition of krukenberg tumor by medical. Krukenberg tumor is a wellknown ovarian metastasis, usually of signet ring cell carcinoma in female. Krukenberg carcinoma genetic and rare diseases information. Krukenberg tumor article about krukenberg tumor by the free. Sonographic findings in 16 cases of krukenberg tumor from gastric carcinoma were analyzed. Krukenberg tumor without leaving macroscopic residual lesions is difficult in many cases, and it has been reported that the median duration of survival ranges from 7. In order to analyze the clinical characteristics and prognostic factors, we retrospectively investigated 128 patients who were diagnosed with krukenberg tumor between january, 1990 and december, 2010. Palliative surgery for krukenberg tumors 12year experience and. The histopathological diagnosis confirms ovarian adnexal metastasis of colon adenocarcinoma. The comparative rarity of the krukenberg tumor is shown by the scant number which have been reported in the medical literature. All the patients who were suspected of having a krukenberg tumor, underwent standard imaging studies to identify the extent of disease and the resectability. On microscopic examination, composed of cells with clear cytoplasm that contains glycogen hob nail cells.
Krukenberg tumor is a rare tumor accounting for 12% of all ovarian tumors alagha, 2006. Intratumoral heterogeneous f18 fluorodeoxyglucose uptake. Bilateral ovarian krukenberg tumor at midgestation dergipark. Pdf an uptodate understanding of the krukenberg tumor. The overall survival in our patients was two months. They are in most instances bilateral and produce a. Krukenberg tumors represent metastases to the ovary and convey.
Krukenberg tumor survival rate, prognosis, symptoms, treatment. Click on the link to view a sample search on this topic. The prognosis of a patient with krukenberg tumor is extremely poor with average survival time between 3 and 10 months. Although krukenberg tumor can occur in people of all age groups, the average age is fixed at 45 years. In most cases, the cancer starts from the ovary itself while in few cases accounting for 1 to 2% of the total, the cancer metastasizes into the ovary. Files are available under licenses specified on their description page. Clinical analysis of krukenberg tumours in patients with. Oct 25, 2018 brenner tumor of the ovary is a solid, abnormal growth tumor on the ovary. The chart showing pdf series, word series, html series, scan qr codes.
A krukenberg tumor is an ovarian metastasis of a gastric tumor and accounts for 12% of all ovarian tumors 1. If you would like a large, unwatermarked image for your web page or blog, please purchase the appropriate license. Cancer, krukenberg tumor statpearls ncbi bookshelf. Krukenberg tumor is named after friedrich ernst krukenberg who described five cases of krukenberg tumors in 1896 while working as a student in a laboratory in germany. Thirty percent of all ovarian neoplasms occurring during. Dec 12, 2018 medical definition of krukenberg tumor. Krukenbergs tumorsaremetastatic tumorsoftheovarythat account for510% ofovarian tumors andthatcausemajor problems inradiologic orpathologic diagnosis 5. Krukenberg tumor is a rare metastatic signet ring cell tumor of the ovary, accounting for 12% of all ovarian tumors. The colon and stomach are the most common primary tumors to result in ovarian metastases, followed by the breast, lung, and contralateral ovary.
About 5% of brenner tumors are cancerous malignant or have a small chance of spreading beyond its original location borderline. Sep 02, 2015 krukenberg tumor is a rare metastastic tumor of the ovary, characterized by poor prognosis. Pubmed is a searchable database of medical literature and lists journal articles that discuss krukenberg carcinoma. Masson 1 in 1934 reported 5 cases observed at the mayo clinic from 1909, although he stated that in earlier files there are records of other tumors which might. A krukenberg tumor is a rare tumor of the ovary derived from metastatic gastrointestinal tissue, most common from gastric cancer. Even if the historical timeline dates back to sir james. Krukenberg tumors of gastric origin versus colorectal origin.
The factors of poor prognosis in our patients are the late diagnosis, presence of ascites and age of. Occasionally krukenberg tumors have endocrine function and, as a consequence, some patients demonstrate hirsutism and virilization. Management of synchronous krukenberg tumors from gastric. Only about 1% to 2% of all ovarian tumors are krukenberg tumor but in some countries like korea, japan and china where the incidence of stomach cancer is very high this rare disease is not so uncommon 5 6. Krukenberg tumor is typically free of surface adhesions or peritoneal deposits unlike other ovarian metastasis. A tumor of the ovary that is caused by the spread of metastatic cancer of the gastrointestinal tract. The development of the krukenberg tumor is not from general gastric cancer, but it is a specific form of cancerous growth arises from signet ring cell carcinoma of the stomach and spread to adenocarcinoma of the ovary. A krukenberg tumor from an occult intramucosal gastric. Only 10% of patients survive more than two years after diagnosis. Jan 14, 2017 a krukenberg tumour kt is defined as an ovarian metastasis from a gastrointestinal adenocarcinoma and suggests a terminal condition.
She was referred recurrent cholangiocarcinoma presenting as ovarian krukenberg tumor chuanchi shih 1, yuhcheng yang 1,2,3,4, jerry chengyen lai 4, yuhui huang 1, taoyeuan wang 5, kungliahng wang 1,3,6 1 department of obstetrics and gynecology, mackay memorial hospital, 2 taipei medical university, 3 mackay medicine, nursing and. Stomach is the primary site in most krukenberg tumors 70%. We describe a patient with a metastatic krukenberg tumor caused by an occult primary gastric cancer that was found during an. Appearance of krukenberg tumor from gastric carcinoma. Krukenberg tumor survival rate, prognosis, symptoms. A krukenberg tumor is a rare and potentially deadly cause of elevated serum.
Genetic and rare diseases information center gard po box 8126, gaithersburg, md 208988126 tollfree. Carcinomas of colon, appendix, and breast mainly invasive lobular carcinoma are the next most common primary sites 2. Krukenberg tumor is more commonly observed among women in their fifth decade of lives, with an average around 45 years of age. If you have problems viewing pdf files, download the latest version of adobe reader. Krukenberg tumors, gastric neoplasm, metastasectomy, chemotherapy, prognosis. Krukenberg tumor is a metastatic signet ring cell adenocarcinoma of the ovary, accounting for 1% to 2% of all ovarian tumors. Clinical characteristics and prognostic analysis of.
This study aimed to identify the prognostic factors affecting the survival of patients with kts of colorectal origin who receive cytoreductive surgery. When the primary tumor is not found, the distinction between a metastatic tumor from an occult cancer and a primary krukenberg tumor is challenging. The tumor involved both ovaries in 14 patients with asymmetrical masses in 9 of 14 cases. The aim of this study is to compare the each clinical manifestation related with its mean survival time of krukenberg tumors kts of gastric origin versus with that of colorectal origin. Recurrent cholangiocarcinoma presenting as ovarian krukenberg. The patients ages ranged from 25 to 52 years mean 42 years. Krukenberg tumor arising from bilateral lobular carcinoma in.
Sonographic appearance of krukenberg tumor from gastric. Credit for the recognition of this rare entity belongs to dr ibrahim ramzy 33 who first described, in 1976, the occurrence in a cellular stromal neoplasm of signet ringlike cells figure 1, e but which lacked the mucin of such cells in a krukenberg tumor or the lipid of the signet ringlike cells seen in the sclerosing stromal tumor. Hi there, my mother is 52 years old, she was diagnosed in sept. Pdf on jan 1, 2016, bikash shah and others published an uptodate understanding of the krukenberg tumor mechanism find, read and. Metastatic ovarian tumors in young age are very rare and reported to be 2% of all the cases. These tumors occur with greatest frequency in women about the age of thirtyfive. All stage iv stomach cancer krukenberg tumours messages.
Ethics documents guidelines for the manuscript publishing process. The krukenberg tumor represents ovarian metastases associated with gastric cancer or other gastrointestinal malignancies. The treatment of metachronous krukenberg tumor mkt from gastric cancer remains unexplored. The majority of patients with krukenberg tumor remain asymptomatic or have nonspecific gastrointestinal symptoms. Assessment revealed no intrauterine pregnancy and a small left ovarian cyst. We report even a rare presentation of this rare disease entity. It is important to note that the ovaries can also be a target site for metastasis from unrelated primary tumors, which may not be obvious at the time of the initial diagnosis.
Krukenberg tumors of gastric origin frequency compared to. All structured data from the file and property namespaces is available under the creative commons cc0 license. Full text is available as a scanned copy of the original print version. Medical records of patients who had received cytoreductive surgery and had been pathologically diagnosed with. Although they can occur at any age, most occur between the ages of 30 and 40. A krukenberg tumor refers to a malignancy in the ovary that metastasized from a primary site, classically the gastrointestinal tract, although it can arise in other tissues such as the breast. A case of virilization induced by a krukenberg tumor from. Krukenberg tumor presenting as back pain and a positive urine. May 10, 2012 clear cell carcinoma clear cell ovarian tumors are part of the surface epithelial tumor group of ovarian cancers, accounting for 6% of these cancers. Krukenberg tumor, also known as carcinoma mucocellulare, refers to the signet ring subtype of metastatic tumor to the ovary. You may not embed one of our images on your web page without a link back to our site.
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